Role of the Microflora in the Etiology of Gastro-Intestinal Cancer (R01)

 
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    CFDA#

    93.393, 93.396, 93.273     		 

    Funder Type

    Federal Government

    IT Classification

    B - Readily funds technology as part of an award

    Authority

    U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH)

    Summary

    This program seeks to advance our mechanistic understanding of microflora influences on Gastro-Intestinal (GI) carcinogenesis. Recent advances in the knowledge of GI microflora composition and function have generated a flood of new information, technologies, and capabilities that may for the first time allow mechanistic investigations of very complex, networked host/microbiome interactions on a systems wide scale. This program encourages investigators to ingrate this new information into hypothesis-driven studies that can define and validate molecular mechanisms that may determine microbe-induced carcinogenic outcomes. The scope of this program is limited to basic science studies that investigate putative molecular mechanisms of GI microbial carcinogenesis. Although the scope of this program is limited to hypothesis driven mechanistic studies, the use of human clinical samples is encouraged.

    Examples of appropriate projects include, but are not restricted to the following:
    • Studies of mechanisms of microbe-induced DNA damage, chromosomal instability, or inhibition of DNA repair pathways;
    • Proteomic analyses that couple bacterial modification of bile acids with dysregulated proliferation signals in intestinal epithelial cells;
    • Studies of mechanisms of precancerous changes in intestinal epithelial cells in response to microflora perturbations;
    • Studies that determine the contribution of specific innate and adaptive immune signaling pathways to microbe-induced GI tumors.
    • Microflora-induced changes in tumor microenvironment (e.g. stromal or stem cell signaling, or paneth cell depletion) with role in modifying tumor risk or progression;
    • Studies of host or microbial factors that contribute to increased susceptibility or protective effects against GI cancers
    • Studies that elucidate the effect of environmental factors or agents (drugs/foods) on microbially induced tumors.
    • Mechanisms by which microbially generated food metabolites may influence cancer risk and prevention.
    • Explore the mechanisms by which differences in diet induce changes in microflora and modify cancer risk and progression.
     

    History of Funding

    None is available. 

    Additional Information

    The human gastrointestinal tract is colonized by a complex microbial community comprising thousands of strains whose individuals total an order of magnitude greater in number than that of somatic cells in the human body. These microbes are primarily bacterial, but fungi, archea, and viruses also comprise the community. In addition, the collective genetic material of the microflora, the microbiome, is estimated to encode 100 times the number of genes in the human genome. Humans thus carry a vastly understudied and complex ecosystem composed of our own unique GI mucosal tissue interacting dynamically with trillions of foreign organisms and their metabolic products.

    Contacts

    Alice C. Wong

    Alice C. Wong
    U.S. Department of Health and Human Services
    National Cancer Institute (NCI)
    BG 9609 RM 2W456
    9609 Medical Center Dr Mail Stop: 9701
    Rockville, MD 20850
    (240) 276-6299
     

  • Eligibility Details

    Eligible applicants include:

    • Higher Education Institutions
      • Public/State Controlled Institutions of Higher Education
      • Private Institutions of Higher Education
      • The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
        • Hispanic-serving Institutions
        • Historically Black Colleges and Universities (HBCUs)
        • Tribally Controlled Colleges and Universities (TCCUs)
        • Alaska Native and Native Hawaiian Serving Institutions
        • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
    • Nonprofits Other Than Institutions of Higher Education
      • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
      • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
    • For-Profit Organizations
    • Small Businesses
    • For-Profit Organizations (Other than Small Businesses)
    • Governments
      • State Governments
      • County Governments
      • City or Township Governments
      • Special District Governments
      • Indian/Native American Tribal Governments (Federally Recognized)
      • Indian/Native American Tribal Governments (Other than Federally Recognized)
      • Eligible Agencies of the Federal Government
      • U.S. Territory or Possession
    • Independent School Districts
    • Public Housing Authorities/Indian Housing Authorities
    • Native American Tribal Organizations (other than Federally recognized tribal governments)
    • Faith-based or Community-based Organizations
    • Regional Organizations
    • Non-domestic (non-U.S.) Entities (Foreign Institutions)

    Deadline Details

    Applications are due by 5:00 p.m., local time of applicant organization, on the following dates: November 4, 2014; March 3, 2015; November 4, 2015; March 3, 2016; November 4, 2016; March 3, 2017. 

    Award Details

    The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are not limited but need to reflect the actual needs of the proposed project. The total project period may not exceed 5 years. Cost sharing/matching is not required. 

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